A Mechanism of Action of Staphylococcal Enterotoxin Poisoning

摘要

These studies provide no information concerning the possible role of the central nervous system in the pathogenesis of acute staphylococcal toxin reactions, nor to the cause of vomition and diarrhea. They do suggest that (a) the toxin is bound initially to WBC's and albumin, (b) that toxin-bound WBC's are trapped in the lung, (c) that the lungs develop increased weight due to interstitial fluid accumulation which occurs coincident with the loss of vascular fluid, but with the unchanged total body water, ICW and ECF, and (d) that re-challenged and resistant animals handle toxin in a different fashion, evidenced by an early increased accumulation of I 131 label in the liver and an increased clearance of I 131 free of protein by the kidney and thryoid. (Author)