B B STAPHYLOCOCCAL ENTEROTOXIN B VACCINE OF STAPHYLOCOCCAL ENTEROTOXIN B MUTANT INHIBITING TOXIC ACTIVITY AND METHOD THEREOF

摘要

The present invention relates to a vaccine which inhibits toxicity by making a mutation through an amino acid substitution in a Staphylococcus aureus enterotoxin B (SEB) protein. More specifically, the 23rd and 90th amino acids from the N-terminus of the major histocompatibility complex (MHC) and T-cell receptor (TCR) binding sites of SEB are replaced with alanine (alanine, Ala) or replacing the 23rd, 90th, 110th and 177th amino acids with Alanine (Alanine, Ala) to remove the binding force of MHC or TCR to remove the toxin-resistant Staphylococcus enterotoxin B type vaccine And the thus prepared yellow staphylococcal enterotoxin type B bag can be used as a composition for preventing and treating SEB poisoning.