In Vitro Effectiveness of Topical Applications of Low Concentration Stannous Fluoride Solutions

摘要

Laboratory studies were carried out (a) to measure the protection afforded dental enamel by the 4-minute topical application of stannous fluoride solutions of low concentration, (b) to study the effect of duration of topical application, and (c) to determine the effect of sodium chloride on the protective performance of a 0.1% stannous fluoride solution. A total of 880 phosphorus determinations was carried out in testing 440 extracted human molar teeth. Protection afforded by the low concentration topical application varied from 69.1% for the 1% solution to 41.3% for the 0.05% preparation. The optimal duration of topical application was sought, and protective effectiveness was found to increase significantly during the second minute of exposure to stannous fluoride solution. The addition of 3.0%, 5.0%, and 10.0% sodium chloride to a 0.1% stannous fluoride solution did not significantly alter protective capacity. However, protection was significantly decreased by the addition of 20% sodium chloride. (Author)