Treatment of Louse-Borne Typhus Fever with Chloramphenicol, Tetracycline or Doxycycline.

摘要

Thirty patients with serological evidence of typhus fever were treated with a ten-day course of oral chloramphenicol or tetracycline, or with a single oral dose of doxycycline. The effectiveness of each antibiotic was assessed by following clinical and laboratory variables. There were no differences among the three groups in their response to treatment; no relapses occurred following treatment. Single-dose doxycycline appears to be as effective as conventional treatment with chloramphenicol or tetracycline for the treatment of typhus fever, but its use is limited by difficulties in differentiating typhus from enteric fevers during the early stages of disease. (Author)