The Role of Altered Intestinal Permeability in the Pathogenesis of Salmonella Diarrhea in the Rhesus Monkey.

摘要

To examine the role of altered permeability in Salmonella diarrhea the authors studied intestinal histology, water and electrolyte transport, clearance of intravenously injected (C(14)) erythritol and ((C3)) mannitol, and changes in transmural electrical potential difference in normal and Salmonella-infected rhesus monkeys. In normal animals, absorption of water and sodium occurred in jejunum, ileum, and colon and a gradient of diminishing permeability from jejunum to ileum to colon for both erythritol and mannitol was observed. Permeability as measured by determining permeability coefficients was not increased by Salmonella infection and in fact was significantly reduced for erythritol in the jejunum of infected animals. Perfusion with hypertonic erythritol and mannitol produced the same streaming potentials (delta PD) in control and infected animals, indicating no differences in transmucosal permeability.