Environmental Factors Involved in the Development of Tolerance to Behavior Effects of Delta-9-Tetrahydrocannabinol.

摘要

Squirrel monkeys were trained under a variety of behavioral procedures, and then Delta-9-tetrahydrocannabinol was administered daily until tolerance developed. The aim of these experiments is to examine the interaction between behavioral procedures and the development of tolerance to behavioral effects of Delta-9-tetrahydrocannabinol. Three classes of experiments were performed. The first group of experiments examined the roles of behavioral 'cost' and baseline response rates as determinants of tolerance development. Two complementary experiments in which either high or low rates were compared with moderate response rates were conducted. The second experiment dealt with task complexity. The experiment examined the interaction of repeated drug administration with the length of a complex response sequence. The last experiment compared tolerance development across different motivations. Equivalent performances were established under three different motivational sets, and two doses were tested.