Pethidine Rash: Its Influence on Peroperatory Hemorrhage (Rash a la Pethidine: Son Influence sur L'Hemmorragie Peroperatoire).

摘要

The i.v. injection of pethidine can bring about allergic phenomena due to the endogenous release of histamine. The histamine thus released brings about vasomotor paralysis of the vessels in the muscular and skin territories and, because of that, perhaps in the beginning abnormal bleeding, provided system tension remains stable. On the other hand, if there is a concomitant tension drop, the bleeding remains within normal limits. (Author)