Lymphocyte Changes in Normal Apheresis Donors.

摘要

Normal apheresis donors were studied to determine if any significant changes occur in the peripheral blood lymphocyte populations. Apheresis donors do have a significant reduction in the number of circulating B-cells following apheresis procedures. The long-term health effects of this B-lymphocyte loss is not known. No change in the ratio of helper to suppressor T-cells was observed when examined by monoclonal anti-human T-cell antibodies. Donor age and previous apheresis procedures did not appear to effect lymphocyte loss during apheresis. However, different apheresis instruments did show significant differences in the number of lymphocytes removed during normal apheresis procedures.