Biochemical and Genetic Markers in Aggressiveness and Recurrence of Prostate Cancer: Race-Specific Links to Inflammation and Insulin Resistance.

摘要

This proposal is driven by hypothesis that certain biological factors associated with metabolic syndrome may play a role in racial differences in prostate cancer (PCa) aggressiveness and prognosis. This is the first study to include large numbers of African American men in an evaluation of metabolic syndrome and the first to study the association between metabolic syndrome and PCa recurrence by race. Our hypothesis is being tested in 2 Aims: 1) To quantitatively assess levels of multimeric adiponectin complexes and selected biochemical markers related to inflammation, insulin resistance and oxidative stress in serum of newly diagnosed PCa patients with non-aggressive and aggressive disease, and examine racial differences in statistical correlations between these biomarkers and adiponectin in PCa patients with aggressive disease; and 2) determine if there are differences in single nucleotide polymorphisms (SNPs) in selected candidate genes implicated in metabolic syndrome, obesity, chronic inflammation inflammation, and oxidative stress in PCa patients with aggressive and non-aggressive disease, and determine how these differences predict the risk of aggressive PCa and disease recurrence by race. We predict that this work should identify novel biomarkers for detection and prognosis of aggressive PCa and provide basis for future studies of mechanisms that drive racial disparities in PCa aggressiveness and outcome.