Effects of Acute Acetylcholinesterase Inhibition by Pyridostigmine Bromide Injection in Euvolemic and Hypovolemic Conscious Swine

摘要

The effects of acute reduction of blood cholinesterase activity, induced by pyridostigmine bromide injection, on physiological and biochemical parameters were assessed in conscious swine with and without hemorrhagic hypotension. Pyridostigmine administration reduced red blood cell acetylcholinesterase (AChE) activity by 61% with values returning to basal values within 3 hrs in both euvolemic and hypovolemic animals. In hypovolemic animals plasma AChE activity was reduced by 35% compared to 14% in euvolemic animals. The greater reduction with hypovolemia was due to 14% decrease during hemorrhage. The acute reduction of AChE activity by pyridostigmine injection in euvolemic and hypovolemic conscious swine did not significantly alter a range of biochemical and physiological parameters. Acute transient symptoms of reduced AChE activity were noted in a few of the hemorrhaged animals.