Mutagenic Potential of 1,3-Bis(3-(1-Pinacoloxymethyl 1-(Imidazolium)Propane Dichloride Monohydrate in the Ames Salmonella/Mammalian Microsome Mutagenicity Test

摘要

1, 3-bis(3-(pinacoloxymethyl) imidazolium)imidazolium)propane dichloride monohydrate was synthesized for a United States Army Medical Research and Development Command program charged with developing more effective oximes for treatment of nerve agent poisoning. The Ames Test is one of a series of tests in which these compounds will be evaluated to determine their relative potential for further development. The mutagenic potential of 1,3-bis(3-(1-pinacoloxymethyl imidazolium) propane dichloride monohydrate was assessed by using the Ames Salmonella/Mammalian Microsome Mutagenicity Test. Tester strains TA97, TA98, TA100, TA102, TA1535, TA1537, and TA1538 were exposed to doses ranging from 0.04 mg/plate to 0.000128 mg/plate. The test compound was not mutagenic under conditions of this test. Keywords: Genetic toxicology, Oximes, Antidotes. (aw)