Developmental Toxicity Potential of Hydroxyurea, a Positive Control, in Rabbits

摘要

The developmental toxicity potential of hydroxyurea was tested in pregnant New Zealand White rabbits. Hydroxyurea was administered by oral gavage on Days 6 through 18 of gestation. Dose levels tested were 0, 25, 50, 150, 200, 225, 300, and 450 mg/kg/day. Fetuses were delivered be cesarean section on Day 29 and weighed, examined externally, and processed in either Bouin's solution for visceral examination or alizarin red stain for skeletal examination. Pregnant females in the 225, 300, and 450 mg/kg/day groups had 100% resorptions. Hydroxyurea at dose levels of 50, 150, and 200 225, 300, and 450 mg/kg/day produced developmental toxic effects in New Zealand White rabbits. Malformations occurring in the 50, 150, and 200 mg/kg/day groups were underdevelopment of the heart atria, malformed tongue, situs inversus of the esophagus and stomach, cervical ribs, 14 pairs of ribs, and extra vertebrae. Keywords: Developmental toxicology, Teratology. (aw)