Effect of Soman Poisoning on Hematology and Coagulation Parameters in Rabbits

摘要

The effects of soman poisoning on hematological parameters (counts of red blood cells (RBC), white blood cells (WBC) and platelets and measurement of hematocrit), coagulation parameters (prothrombin time, activated partial thromboplastin time, thrombin time and concentrations of fibrinogen, factor V, factor VII and factor XI and serum biochemistry (concentration of albumin, protein, calcium, cholesterol, triglycerides, blood urea nitrogen (BUN), magnesium and creatinine and activities of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, cholinesterase, creatinine phosphokinase (CPK), hydroxybutyrate dehydrogenase and amylase) were determined at 1,2,4,24 and 48 hr after poisoning of rabbits. There are significant decreases in the RBC counts in all treatment groups which were measured initially and were reflected by parallel decreases in the hematocrit values. These changes were probably due to an increase in the hemolysis of the RBC rather than an decrease in the production of RBC. There were minor changes in the coagulation parameters. Generally, the fibrinogen content increased. From the results of this study, although there were minor hematological and coagulation changes following exposure to soman, these would probably neither contribute to the toxicity of the nerve agent nor complicate the treatment of a mixed casualty (ie. those individuals who have not only been exposed to nerve agent and received therapy but who also require conventional treatment for a traumatic injury). (kt)