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The Journal of toxicological sciences

The Journal of toxicological sciences

中文名称：毒理学杂志

ISSN：0388-1350
出版周期：-

发文量：1059

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1.A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks

机译：饮用水54周大鼠二苯基胂酸的致病性研究104周
- 作者：Yamaguchi Takashi;Gi Min;Fujioka Masaki;Doi Kenichiro;Okuno Takahiro;Kakehashi Anna;Wanibuchi Hideki
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第4期
- Diphenylarsinic acid;
- Carcinogenicity study;
- F344 rats;
2.Dexamethasone-induced hepatomegaly and steatosis in larval zebrafish

机译：地塞米松诱导幼虫斑马鱼的肝肿瘤和脂肪变性
- 作者：Yin Guojun;Cao Liping;Du Jinliang;Jia Rui;Kitazawa Takio;Kubota Akira;Teraoka Hiroki
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第4期
- Glucocorticoid;
- Hepatomegaly;
- Liver;
- Steatosis;
- Zebrafish;
3.Alpha-PVP induces the rewarding effect via activating dopaminergic neuron

机译：Alpha-PVP通过激活多巴胺能神经元诱导奖励效果
- 作者：Hataoka Kyoko;Kaizaki-Mitsumoto Asuka;Numazawa Satoshi
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
4.Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis

机译：异常杂志性能酶促药物代谢酶表达的发育变化
- 作者：Mori Junpei;Sanoh Seigo;Kashiwagi Keiko;Hanada Hideki;Shigeta Mitsuki;Suzuki Ken-ichi T.;Yamamoto Takashi;Kotake Yaichiro;Sugihara Kazumi;Kitamura Shigeyuki;Kashiwagi Akihiko;Ohta Shigeru
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Xenopus tropicalis;
- Drug-metabolizing enzyme;
- Cytochrome P450;
- Metamorphosis;
- Thyroid hormone;
5.Sex differences in the excretion levels of traditional and novel urinary biomarkers of nephrotoxicity in rats

机译：大鼠肾毒性传统和新型尿生物标志物排泄水平的性差异
- 作者：Tsuji Satoshi;Sugiura Masayuki;Tsutsumi Shunsuke;Yamada Hisaharu
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Rat;
- Urinary biomarker;
- Sex difference;
- Castration;
6.Concentration-dependent roles of DMT1 and ZIP14 in cadmium absorption in Caco-2 cells

机译：Caco-2细胞中镉吸收中DMT1和ZIP14的浓度依赖性作用
- 作者：Fujishiro Hitomi;Hamao Satoko;Tanaka Rina;Kambe Taiho;Himeno Seiichiro
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Cadmium;
- Transport;
- DMT1;
- ZIP14;
- Enterocyte;
- Caco-2;
7.Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity

机译：由SenP3降解介导的Sumo-2/3-ylation的增加是对镉诱导的胱天蛋白酶3依赖性细胞毒性的保护性
- 作者：Luo Jia;Gurung Sonam;Lee Laura;Henley Jeremy M.;Wilkinson Kevin A.;Guo Chun
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Cadmium;
- Apoptosis;
- Cell stress;
- SUMOylation;
- SENP3;
8.Development of a modified 3T3 Neutral Red Uptake Phototoxicity Test protocol for evaluation of poorly water-soluble substances

机译：用于评价水溶性物质的改性3T3中性红色摄取光毒性试验方案的研制
- 作者：Toyoda Akemi;Sugiyama Maki;Furihata Seiichiro;Nishizumi Keiji;Omori Takashi;Itagaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- 3T3 NRU PT;
- Phototoxicity;
- Photoirritation;
- Poorly water-soluble;
9.Usefulness of urinary biomarkers for nephrotoxicity in cynomolgus monkeys treated with gentamicin, cisplatin, and puromycin aminonucleoside

机译：用庆大霉素，顺铂和嘌呤霉素氨基核苷的鱼糜猴尿毒性尿毒性尿毒性的有用性
- 作者：Uchino Hiroshi;Fujishima Junko;Fukuoka Kaori;Lwakiri Teppei;Kamikuri Akira;Maeda Hidenori;Nakama Kazuhiro
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Urinary biomarker;
- Nephrotoxicity;
- Cynomolgus monkeys;
10.Multidirectional analyses of hepatic chronotoxicity induced by cadmium in mice

机译：小鼠镉诱导的肝计量毒性的多向分析
- 作者：Miura Nobuhiko;Yoshioka Hiroki;Ashimori Atsushige;Ohtani Katsumi;Hasegawa Tatsuya;Hwang Gi-Wook;Ikeda Masayuki;Nonogaki Tsunemasa
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Chronotoxicology;
- Cadmium;
- Risk assessment;
- Reproducibility of animal experiments;
- Shift work;
11.Assessment of amiodarone-induced phospholipidosis in chimeric mice with a humanized liver

机译：用人源化肝脏评估嵌合小鼠中胺碘酮诱导的磷脂
- 作者：Sanoh Seigo;Yamachika Yuto;Tamura Yuka;Kotake Yaichiro;Yoshizane Yasumi;Ishida Yuji;Tateno Chise;Ohta Shigeru
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Chimeric mice with humanized liver;
- Amiodarone;
- Phospholipidosis;
- Phosphatidylcholine;
- Imaging mass spectrometry;
12.Copper diethyldithiocarbamate as an inhibitor of tissue plasminogen activator synthesis in cultured human coronary endothelial cells

机译：铜二乙基硫代氨基甲酸酯作为培养的人冠状动脉内皮细胞中组织纤溶酶原激活剂合成的抑制剂
- 作者：Fujie Tomoya;Okino Shiori;Yoshida Eiko;Yamamoto Chika;Naka Hiroshi;Kaji Toshiyuki
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Copper complex;
- Endothelial cell;
- Fibrinolysis;
- Plasminogen activator;
13.Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol

机译：YAP激活的恢复从乙醇中从凋亡死亡中救出HL-1心肌细胞
- 作者：Noritake Kanako;Aki Toshihiko;Kimura Moe;Funakoshi Takeshi;Unuma Kana;Uemura Koichi
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Ethanol;
- YAP;
- Cardiomyocytes;
- Apoptosis;
14.A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis

机译：使用Heparg细胞预测药物诱导的磷脂的细胞基测定
- 作者：Tomida Takafumi;Ishimura Masakazu;Iwaki Masahiro
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- HepaRG cells;
- Loratadine;
- LYSO-ID Red;
- Phospholipidosis;
15.Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi

机译：河内越南越南鱼类消费的毛发水平
- 作者：Van Anh Thi Hoang;Hien Thu Thi Do;Agusa Tetsuro;Koriyama Chihaya;Akiba Suminori;Ishibashi Yasuhiro;Sakamoto Mineshi;Yamamoto Megumi
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Methylmercury;
- Fish consumption;
- Vietnamese;
- Selenium;
16.Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes

机译：短QT和Long QT综合征麻醉兔模型机电窗口的特点
- 作者：Limprasutr Vudhiporn;Saengklub Nakkawee;Meedech Pradtana;Kijtawornrat Anusak;Hamlin Robert L.
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第5期
- Electromechanical window;
- Long QT;
- Rabbit;
- Safety Pharmacology;
- Short QT;
17.Possible mechanism for the polychlorinated biphenyl-induced liver-selective accumulation of thyroxine in rats

机译：多氯联苯诱导的大鼠甲状腺素肝脏选择性积累的可能机制
- 作者：Kato Yoshihisa;Fujii Aki;Haraguchi Koichi;Fujii Yukiko;Atobe Kazutaka;Endo Tetsuya;Kimura Osamu;Koga Nobuyuki;Ohta Chiho;Yamada Shizuo;Degawa Masakuni
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Kanechlor-500;
- Polychlorinated biphenyl;
- Thyroxine;
- Liver;
- L-type amino acid transporter 1;
18.The effects of ethylene glycol monomethyl ether on female reproductive system in juvenile rats

机译：乙二醇单甲醚对幼年大鼠雌性生殖系统的影响
- 作者：Taketa Yoshikazu;Mineshima Hiroshi;Ohta Etsuko;Nakano-Ito Kyoko
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Estrous cycle;
- Ethylene glycol monomethyl ether;
- Female pubertal development;
- Juvenile rats;
- Reproductive organs;
19.Synergistic cytotoxicity caused by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells

机译：通过在培养的血管内皮细胞中形成铜和2,9-二甲基-1,10-菲咯啉的复合物引起的协同细胞毒性
- 作者：Nakamura Takehiro;Yoshida Eiko;Fujie Tomoya;Ogata Fumihiko;Yamamoto Chika;Kawasaki Naohito;Kaji Toshiyuki
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Copper complex;
- Cytotoxicity;
- Endothelial cell;
- Organic-inorganic hybrid molecule;
- Bio-organometallics;
20.Macrophage differentiation induced by PMA is mediated by activation of RhoA/ROCK signaling

机译：PMA诱导的巨噬细胞分化是通过RHOO /摇滚信令的激活介导的
- 作者：Yang Lifeng;Dai Fan;Tang Lian;Le Yulan;Yao Wenjuan
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- PMA;
- Macrophage;
- RhoA/ROCK signaling pathway;
- ROCK inhibitor;
21.Evaluation of the human relevance of the constitutive and rostane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin

机译：合成拟除虫菊虫胚芽素母鸡蛋白的组成型和疏松肠道受体介导的人体相关性的人体相关性的评价
- 作者：Okuda Yu;Kushida Masahiko;Kikumoto Hiroko;Nakamura Yoshimasa;Higuchi Hashihiro;Kawamura Satoshi;Cohen Samuel M.;Lake Brian G.;Yamada Tomoya
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Carcinogenesis;
- Liver tumor;
- Nongenotoxic;
- MOA;
- Cell proliferation;
- Humanized mice;
22.Effect of dibutyltin on placental and fetal toxicity in rat

机译：二丁酯对大鼠胎盘胎儿胎儿毒性的影响
- 作者：Furukawa Satoshi;Tsuji Naho;Kobayashi Yoshiyuki;Yamagishi Yoshikazu;Hayashi Seigo;Abe Masayoshi;Kuroda Yusuke;Kimura Masayuki;Hayakawa Chisato;Sugiyama Akihiko
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Dibutyltin;
- LA-ICP-MS;
- Malformation;
- Placenta;
- Rat;
23.Actual consumption amount of personal care products reflecting Japanese cosmetic habits

机译：反映日本化妆品习惯的个人护理产品的实际消费量
- 作者：Yamaguchi Masahiko;Araki Daisuke;Kanamori Takeshi;Okiyama Yasuko;Seto Hirokazu;Uda Masaki;Usami Masahito;Yamamoto Yutaka;Masunaga Takuji;Sasa Hitoshi
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Cosmetics;
- Exposure assessment;
- Applied amount;
- Usage frequency;
- Seasonal fluctuation;
- Safety assessment;
24.Background data on NOD/Shi-scid IL-2R gamma(null) mice (NOG mice)

机译：Nod / shi-scid IL-2rγ（null）小鼠（nog mice）的背景数据
- 作者：Kasahara Kenichiro;Fukunaga Yachiyo;Igura Saori;Andoh Rie;Saito Tsubasa;Suzuki Isamu;Kanemitsu Hiroyuki;Suzuki Daisuke;Goto Ken;Nakamura Daichi;Mochizuki Masahiro;Yasuda Masahiko;Inoue Ryo;Tamura Kazutoshi;Nagatani Mariko
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- NOG mice;
- Background data;
- Immuno-deficient;
- Lymphoid hypoplasia;
- Spongiotic changes;
- Tubular aggregate;
25.Perinatal exposure to tetrabromobisphenol A (TBBPA), a brominated flame retardant, exacerbated the pneumonia in respiratory syncytial virus (RSV)-infected offspring mice

机译：围产期暴露于四溴双酚A（TBBPA），溴化阻燃剂，加剧了呼吸道合胞病毒（RSV）的肺炎（RSV）的后代小鼠
- 作者：Watanabe Wataru;Hirose Akihiko;Takeshita Tomomi;Hashiguchi Seiko;Sakata Kentaro;Konno Katsuhiko;Miyauchi Aki;Akashi Toshi;Yoshida Hiroki;Sugita Chihiro;Kurokawa Masahiko
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- TBBPA;
- RSV;
- Pneumonia;
- IL-24;
26.Sub-toxic concentrations of nano-ZnO and nano-TiO2 suppress neurite outgrowth in differentiated PC12 cells

机译：纳米ZnO和纳米TiO2的副毒性浓度抑制了分化的PC12细胞中的神经沸物过度
- 作者：Irie Tomohiko;Kawakami Tsuyoshi;Sato Kaoru;Usami Makoto
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Nano-ZnO;
- Nano-TiO2;
- PC12;
- Neurite outgrowth;
27.Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling

机译：由于缺乏FXR信号传导，鱼油饲料逆转肝肿大并破坏肝功能
- 作者：Miyata Masaaki;Shinno Kouhei;Kinoshita Tomoki;Kinoshita Yuichi;Sugiura Yoshimasa
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Fish oil;
- FXR;
- Hepatomegaly;
- Steatosis;
28.Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis

机译：基于α-萘硫代噻噻烷酸甲酯诱导的胆汁淤积的中度肝功能障碍大鼠模型的表征
- 作者：Bothe Melanie K.;Meyer Christoph;Mueller Udo;Queudot Jean-Christophe;Roger Virginie;Harleman Johannes;Westphal Martin
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Animal model;
- Liver dysfunction;
- Cholestasis;
- Alpha-naphthylisothiocyanate;
29.Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis

机译：利用人诱导的多能干细胞衍生心肌细胞和基因表达分析评估药物的心律源潜力评估系统
- 作者：Higa Arisa;Hoshi Hirotaka;Yanagisawa Yuka;Ito Emi;Morisawa Gaku;Mai Jun-ichi;Watanabe Shinya;Takagi Motoki
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
30.Change in redox state and heat shock protein expression in an Indian major carp Cirrhinus cirrhosus exposed to zinc and lead

机译：在印度主要鲤鱼Cirrhinus Cirrhosus暴露于锌和铅的氧化还原状态和热休克蛋白表达的变化
- 作者：Moniruzzaman Mahammed;Midday Puja;Dhara Anindita;Das Debjit;Ghosal Indranath;Mukherjee Debosree;Chakraborty Suman Bhusan
- 期刊名称：《The Journal of toxicological sciences》 | 2017年第6期
- Heat shock protein;
- Antioxidant enzymes;
- Zinc;
- Lead;
- Cirrhinus cirrhosus;
31.Relationship between low midazolam metabolism by cytochrome P450 3A in mice and the high incidence of birth defects

机译：细胞色素P450 3A在小鼠中低咪达唑仑代谢的关系及出生缺陷的高发病率
- 作者：Kitaoka Satoshi;Hatogai Jo;Iimura Ryuki;Yamamoto Yuka;Oba Konomi;Nakai Mami;Kusunoki Yoshiki;Ochiai Wataru;Sugiyama Kiyoshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Cytochrome P450;
- CYP3A11;
- CYP3A16;
- Pregnancy;
- Liver;
- Midazolam;
32.Radical scavenging effects of 1-naphthol, 2-naphthol, and their sulfate-conjugates

机译：1-萘酚，2-萘酚及其硫酸盐 - 缀合物的根本清除作用
- 作者：Sugahara Shintaro;Fukuhara Kumiko;Tokunaga Yuki;Tsutsumi Shuhei;Ueda Yuto;Ono Masateru;Kurogi Katsuhisa;Sakakibara Yoichi;Suiko Masahito;Liu Ming-Cheh;Yasuda Shin
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- 1-Naphthol;
- 2-Naphthol;
- 1-Naphtyl sulfate;
- 2-Naphthyl sulfate;
- Sulfate conjugation;
- Free radical;
33.Effects of long-term cadmium exposure on urinary metabolite profiles in mice

机译：长期镉暴露对小鼠尿代谢物谱的影响
- 作者：Sarma Sailendra Nath;Saleem Ammar;Lee Jin-Yong;Tokumoto Maki;Hwang Gi-Wook;Chan Hing Man;Satoh Masahiko
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Cadmium;
- Kidney;
- Long-term exposure;
- Urine metabolome;
34.Lethal chronotoxicity induced by seven metal compounds in mice

机译：七金属化合物在小鼠中诱导的致死计量毒性
- 作者：Yoshioka Hiroki;Nonogaki Tsunemasa;Shinohara Yasuro;Suzui Masumi;Mori Yurie;Hwang Gi-Wook;Ohtani Katsumi;Miura Nobuhiko
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Chronotoxicology;
- Circadian rhythm;
- Lethal toxicity;
- Risk assessments;
- Metal toxicity;
35.A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor

机译：在接受酰基CoA的动物中衍生自肠衍生的血浆转氨酶活性的药理学增加：二酰基甘油转移酶（DGAT）1抑制剂
- 作者：Yokoyama Hideaki;Kobayashi Akio;Kondo Kazuma;Oshida Shin-ichi;Takahashi Tadakazu;Masuyama Taku;Shoda Toshiyuki;Sugai Shoichiro
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- DGAT1 inhibitor;
- Small intestine;
- Transaminase;
- ALT;
- AST;
- Fatty acid;
36.Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species

机译：砷酸砷曝光增强了肿瘤坏死因子 - α-反应性氧物种的凋亡诱导效应
- 作者：Singhirunnusorn Pattama;Moolmuang Benchamart;Lirdprapamongkol Kriengsak;Ruchirawat Mathuros
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
37.Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries

机译：细胞色素P450介导的代谢和反应性代谢产物形成对抗癫痫药物诱导的肝损伤的作用
- 作者：Sasaki Eita;Yokoi Tsuyoshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Antiepileptic drug;
- Drug development;
- Drug-induced liver injury;
- Glutathione;
- Reactive metabolite;
- P450;
38.Acute exposure to crotonaldehyde induces dysfunction of immune system in male Wistar rats

机译：急性接触克罗特醛诱导男性Wistar大鼠免疫系统的功能障碍
- 作者：Wang Limeng;Yang Zhihua;Xu Long;Pan Xiujie;Liu Xingyu;Zhao Junwei;Li Xiang;Zhu Maoxiang;Xie Jianping
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Crotonaldehyde;
- Male Wistar rats;
- Immune system;
39.Neurobehavioral effects of postnatal exposure to low-level mercury vapor and/or methylmercury in mice

机译：产后暴露于小鼠低水平汞蒸汽和/或甲基汞的神经障碍效应
- 作者：Yoshida Minoru;Lee Jin-Yong;Satoh Masahiko;Watanabe Chiho
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Mercury vapor;
- Methylmercury;
- Combined exposure;
- Behavioral toxicity;
- Offspring mice;
40.Effect of gestational cadmium exposure on fetal growth, polyubiquitinated protein and monoubiqutin levels in the fetal liver of mice

机译：妊娠期镉暴露对小鼠胎儿肝脏胎儿生长，络合蛋白和单脓性水平的影响
- 作者：Kurita Hisaka;Hasegawa Tatsuya;Seko Yoshiyuki;Nagase Hisamitsu;Tokumoto Maki;Lee Jin-Yong;Satoh Masahiko
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Cadmium;
- Fetal growth retardation;
- Polyubiquitinated protein;
- Polyubiquitin C gene;
41.Development of pain therapies targeting nerve growth factor signal transduction and the strategies used to resolve safety issues

机译：疼痛疗法的发展靶向神经生长因子信号转导和解决安全问题的策略
- 作者：Belanger Patrice;West Christine R.;Browne Mark T.
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Nerve growth factor antibody;
- Tanezumab;
- Fasinumab;
- Fulranumab;
42.Improvement of human cell line activation test (h-CLAT) using short-time exposure methods for prevention of false-negative results

机译：使用短时间曝光方法改善人体细胞系活化试验（H-CLAT）预防假阴性结果
- 作者：Narita Kazuto;Ishii Yuuki;Phuc Thi Hong Vo;Nakagawa Fumiko;Ogata Shinichi;Yamashita Kunihiko;Kojima Hajime;Itagaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Skin sensitization test;
- False-negative results;
- h-CLAT;
- THP-1;
- Allergic contact dermatitis;
43.Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol

机译：大鼠CYP同种型的相对贡献负责Carvedilol的立体选择性代谢
- 作者：Iwaki Masahiro;Niwa Toshiro;Nakamura Yukiko;Kawase Atsushi;Komura Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Chirality;
- CYP enzymes;
- Cytochrome P450;
- Metabolism;
44.Necrosis in human neuronal cells exposed to paraquat

机译：暴露于百草枯的人神经元细胞中的坏死
- 作者：Hirayama Naho;Aki Toshihiko;Funakoshi Takeshi;Noritake Kanako;Unuma Kana;Uemura Koichi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Paraquat;
- BNIP3;
- SH-SY5Y cells;
- Cell death;
45.Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure

机译：ROS介导的线粒体损伤患有支气管上皮细胞凋亡环境PM2.5暴露
- 作者：Jin Xiaoting;Xue Bin;Zhou Qunfang;Su Ruijun;Li Zhuoyu
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Particular matter (PM2.5);
- Mitochondria;
- ROS;
- Bronchial epithelial cells;
- Apoptosis;
46.High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats

机译：高果糖饮食饲料在自发性糖尿病菌革（SDT）大鼠中加速糖尿病肾病
- 作者：Toyoda Kaoru;Suzuki Yusuke;Muta Kyotaka;Masuyama Taku;Kakimoto Kochi;Kobayashi Akio;Shoda Toshiyuki;Sugai Shoichiro
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Fructose;
- Nephrotoxicity;
- Diabetic animal model;
- Uric acid;
- Hyperglycemia;
47.Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine

机译：卤代料麻醉犬交叉研究与卤代甲烷麻醉犬交叉研究对氟苯胺和药代动力学谱的变异性比较
- 作者：Ando Kentaro;Nakamura Yuji;Hagiwara-Nagasawa Mihoko;Harada Hiroyuki;Miyamoto Hiroyoshi;Inamura Naoki;Takagi Kan;Goto Ai;Chiba Koki;Lubna Nur Jaharat;Izumi-Nakaseko Hiroko;Naito Atsuhiko T.;Sugiyama Atsushi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Terfenadine;
- Fexofenadine;
- Cardiac electrophysiology;
- Cross-over study;
- Pharmacokinetic variability;
48.Determination of chemical-specific IgGs in serum by an enzyme-linked immunosorbent assay with partial peptides of human serum albumin

机译：用酶联免疫吸附试验用血清白蛋白的部分肽测定血清中化学特异性IgGs
- 作者：Ishihara Yasuhiro;Ikeda-Ishihara Nami;Koriyama Chihaya;Kakiuchi Noriaki;Tanaka Masayuki;Vogel Christoph F. A.;Kawamoto Toshihiro;Tsuji Mayumi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Chemical-specific IgG;
- ELISA;
- Carbonyl compounds;
49.Zonation of the drug-metabolizing enzyme cytochrome P450 3A in infant mice begins in pre-weaning period

机译：在婴儿小鼠中的药物代谢酶细胞色素p450 3a的分区在断奶前开始
- 作者：Kitaoka Satoshi;Hatogai Jo;Ochiai Wataru;Sugiyama Kiyoshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Zonation;
- Cytochrome P450 3A;
- CYP3A11;
- CYP3A16;
- Fetus;
- Infant;
50.Carcinogenicity of quinoline by drinking-water administration in rats and mice

机译：喹啉毒液通过饮用水施用大鼠和小鼠致癌性
- 作者：Matsumoto Michiharu;Kano Hirokazu;Suzuki Masaaki;Noguchi Tadashi;Umeda Yumi;Fukushima Shoji
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Quinoline;
- Hemangioma;
- Hemangiosarcoma;
- Rats;
- Mice;
51.The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

机译：NOX4在细颗粒物质暴露诱导的小鼠心脏损伤中的参与
- 作者：Wu Fan;Zhang Jinying
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Fine particulate matter;
- Cardiovascular disease;
- Nox4;
- Myocardial apoptosis;
52.A reaction mechanism-based prediction of mutagenicity: alpha-halo carbonyl compounds adduct with DNA by S(N)2 reaction

机译：基于反应机理的致突变性预测：S（n）2反应用DNA加合物加合物
- 作者：Haranosono Yu;Ueoka Hiroki;Kito Gakushi;Nemoto Shingo;Kurata Masaaki;Sakaki Hideyuki
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第3期
- Mutagenicity;
- In silico;
- Molecular orbital;
- S(N)2 reaction;
- alpha-Halo carbonyl;
53.Brain-specific induction of secretoglobin 3A1 expression in mice treated with methylmercury

机译：用甲基汞治疗小鼠批发蛋白3A1表达的脑癌细胞特异性诱导
- 作者：Tsutomu Takahashi;Min-Seok Kim;Takahiro Saito;Jin-Yong Lee;Gi-Wook Hwang;Akira Naganuma
- 期刊名称：《The Journal of toxicological sciences》 | 2013年第6期
- Methylmercury;
- Secretoglobin;
- Scgb3al;
- Brain;
- Induction;
54.Photodynamic therapy using talaporfin sodium induces heme oxygenase-1 expression in rat malignant meningioma KMY-J cells

机译：使用Talaporfin钠的光动力疗法在大鼠恶性脑膜瘤中诱导血红素氧合酶-1表达
- 作者：Takahashi Tsutomu;Suzuki Saki;Misawa Suzuka;Akimoto Jiro;Shinoda Yo;Fujiwara Yasuyuki
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Photodynamic therapy;
- Talaporfin sodium;
- Heme oxygenase-1;
- Malignant meningioma cell;
55.Cytochrome P450-dependent drug oxidation activities in commercially available hepatocytes derived from human induced pluripotent stem cells cultured for 3 weeks

机译：在商业上可获得的肝细胞中衍生自人诱导的多能干细胞培养3周的细胞色素P450依赖性药物氧化活性
- 作者：Murayama None;Yamazaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- iPSC-derived hepatocytes;
- HepaRG cells;
- P450 3A4;
- P450 3A5;
- P450 2C9;
- P450 2C19;
56.Comparing time-series of chemical concentrations in zebrafish (Danio rerio) embryos/larvae exposed to teratogens with different hydrophobicity; caffeine, sodium valproate, and diethylstilbestrol

机译：比较斑马鱼（Danio Rerio）胚胎/幼虫在不同疏水中暴露于畸状的时序 - 胚胎/幼虫; 咖啡因，戊酸钠和二乙基斯特罗罗罗
- 作者：Nawaji Tasuku;Mizoguchi Naohiro;Ono Mika;Matuura Takeshi;Seki Masanori;Teraoka Hiroki
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Zebrafish;
- Developmental toxicity;
- Concentration in embryos/larvae;
- Hydrophobicity;
- Lipid concentration;
57.The profiles and networks of miRNA, lncRNA, mRNA, and circRNA in benzo(a)pyrene-transformed bronchial epithelial cells

机译：苯并（a）芘转化的支气管上皮细胞中MiRNA，LNCrNA，mRNA和CircrNA的谱和网络
- 作者：Jiang Xinhang;Wu Xiaoying;Chen Feiyu;He Wei;Chen Xintong;Liu Linhua;Tang Huanwen
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Human bronchial epithelial cell;
- Transformation;
- Benzo(a)pyrene;
- miRNA;
- lncRNA;
- circRNA;
58.Fluoride-induced iron overload contributes to hepatic oxidative damage in mouse and the protective role of Grape seed proanthocyanidin extract

机译：氟化铁过载导致小鼠的肝氧化损伤以及葡萄籽原霉素提取物的保护作用
- 作者：Niu Qiang;He Ping;Xu Shangzhi;Ma Ruling;Ding Yusong;Mu Lati;Li Shugang
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Fluoride;
- Liver;
- Oxidative stress;
- Iron overload;
- Grape seed proanthocyanidin extract;
59.Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-beta peptides in cells harboring amyloid-beta precursor protein

机译：尼古丁和甲基乙烯基酮，香烟烟雾提取物的主要成分，增加含淀粉样蛋白 - β前体蛋白的细胞中的保护性淀粉样蛋白β肽
- 作者：Ohshima Yoichi;Iwata Kazumi;Ibi Masakazu;Matsumoto Misaki;Katsuyama Masato;Yabe-Nishimura Chihiro
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Alzheimer's disease;
- Amyloid-beta;
- Amyloid precursor protein;
- Methyl vinyl ketone;
- Nicotine;
60.Ether-phosphatidylcholine characterized by consolidated plasma and liver lipidomics is a predictive biomarker for valproic acid-induced hepatic steatosis

机译：醚 - 磷脂酰胆碱，其特征在于固结等离子体和肝脏脂质学是一种预测生物标志物，用于丙甲酸诱导的肝脏脂肪变性
- 作者：Goda Keisuke;Saito Kosuke;Mute Kyotaka;Kobayashi Akio;Saito Yoshiro;Sugai Shoichiro
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Valproic acid;
- Hepatic steatosis;
- Lipidomics;
- Biomarker;
- DILI;
61.Development of an in vitro photosafety evaluation method utilizing intracellular ROS production in THP-1 cells

机译：在THP-1细胞中使用细胞内ROS产生的体外光度评价方法的研制
- 作者：Toyoda Akemi;Itagaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Photosensitivity;
- Phototoxicity;
- Reactive oxygen species;
- CD86;
- CD54;
- Quencher;
62.Bisphenol AF as an activator of human estrogen receptor beta 1 (ER beta 1) in breast cancer cell lines

机译：双酚Af作为乳腺癌细胞系中的人雌激素受体β1（ERβ1）的活化剂
- 作者：Okazaki Hiroyuki;Hirao-Suzuki Masayo;Takeda Shuso;Takemoto Yukimi;Mizunoe Ramu;Haraguchi Koichi;Watanabe Kazuhito;Takiguchi Masufumi;Aramaki Hironori
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Bisphenol AF;
- BPAF;
- ER beta 1;
- MDA-MB-231 cells;
- SK-BR-3 cells;
63.Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat

机译：在2型糖尿病模型大鼠中增加了对Troglitazone诱导的线粒体渗透率过渡的敏感性增加
- 作者：Segawa Masahiro;Sekine Shuichi;Sato Tomoyuki;Ito Kousei
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Diabetes;
- Troglitazone;
- Liver mitochondria;
- Mitochondrial permeability transition;
- Lipid peroxidation;
- Cardiolipin;
64.Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity

机译：谷胱甘肽具有比金属硫蛋白-I / II对无机汞诱导的急性肾毒性更重要的作用
- 作者：Tokumoto Maki;Lee Jin-Yong;Shimada Akinori;Tonyama Chiharu;Satoh Masahiko
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Inorganic mercury;
- Metallothionein;
- Glutathione;
- Nephrotoxicity;
65.Acidic conditions induce the suppression of CD86 and CD54 expression in THP-1 cells

机译：酸性条件诱导THP-1细胞中CD86和CD54表达的抑制
- 作者：Mitachi Takafumi;Mezaki Minori;Yamashita Kunihiko;Itagaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Sensitization;
- pH;
- CD86;
- CD54;
- Allergen;
66.Protective effects of rutin on lipopolysaccharide-induced heart injury in mice

机译：芦丁对小鼠脂多糖诱导心脏损伤的保护作用
- 作者：Liu Xianchu;Zheng Lan;Liu Ming;Mo Yanzhi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Rutin;
- Lipopolysaccharide;
- Heart;
- Anti-oxidant;
- Anti-inflammatory;
67.Effect of the combined compound probiotics with mycotoxin-degradation enzyme on detoxifying aflatoxin B-1 and zearalenone

机译：复合益生菌与霉菌毒素降解酶解毒毒毒素B-1和酸甲酮的效果
- 作者：Huang Weiwei;Chang Juan;Wang Ping;Liu Chaoqi;Yin Qingqiang;Zhu Qun;Lu Fushan;Gao Tianzeng
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Biodegradation;
- Mycotoxin;
- probiotics;
- mycotoxin-degradation enzyme;
- Response surface methodology;
68.Early detection of prostate carcinogens by immunohistochemistry of HMGB2

机译：通过HMGB2的免疫组织化学早期检测前列腺原
- 作者：Suzuki Shugo;Kato Hiroyuki;Fuji Satoshi;Naiki Taku;Naiki-Ito Aya;Yamashita Yoriko;Takahashi Satoru
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Carcinogens;
- Rat;
- Prostate;
- Carcinogenesis;
- HMGB2;
69.Hepatic histopathological changes and dysfunction in primates following exposure to organic arsenic diphenylarsinic acid

机译：在暴露于有机砷二苯基胂酸后，灵活内的肝组织病理学变化和功能障碍
- 作者：Masuda Tomoyuki;Ishii Kazuhiro;Morishita Yukio;Iwasaki Nobuaki;Shibata Yasuyuki;Tamaoka Akira
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Macaca fascicularis;
- Primate;
- Phenyl arsenic compound;
- Long-term exposure;
- Hepatic pathology;
- Hepatic damage;
70.Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice

机译：基于氘 - 肝脏小鼠氘标记的三甲胺的代谢谱，使用药代动力学建模的三甲胺N-氧化物推断的人血浆浓度
- 作者：Shimizu Makiko;Suemizu Hiroshi;Mizuno Sawa;Kusama Takashi;Miura Tomonori;Uehara Shotaro;Yamazaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- PBPK modeling;
- Allometric scaling;
- TMA;
- TMAO;
- Human;
71.Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA

机译：人血清肝脏小鼠药代动力学数据模拟人血浆中Lenalidomide的药代动力学谱的缔合血清中血清白蛋白RNA检测的肝脏毒性
- 作者：Murayama Norie;Suemizu Hiroshi;Uehara Shotaro;Kusama Takashi;Mitsui Marina;Kamiya Yusuke;Shimizu Makiko;Guengerich F. Peter;Yamazaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Immunodeficient mice;
- Transplanted human hepatocytes;
- Thalidomide;
- Hepatoxicity;
- PBPK modeling;
72.Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA

机译：人血清肝脏小鼠药代动力学数据模拟人血浆中Lenalidomide的药代动力学谱的缔合血清中血清白蛋白RNA检测的肝脏毒性
- 作者：Murayama Norie;Suemizu Hiroshi;Uehara Shotaro;Kusama Takashi;Mitsui Marina;Kamiya Yusuke;Shimizu Makiko;Guengerich F. Peter;Yamazaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Immunodeficient mice;
- Transplanted human hepatocytes;
- Thalidomide;
- Hepatoxicity;
- PBPK modeling;
73.Prenatal bisphenol A exposure is associated with medial amygdala neuron hyperresponsiveness to predator odor in rats

机译：产前的双酚暴露与大鼠捕食者气味的内侧杏仁蛋白高反应性有关
- 作者：Fujimoto Tetsuya;Aou Shuji
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第9期
- Amygdala;
- Bisphenol A;
- Odor-responsive neuron;
- Predator odor;
74.Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells

机译：人类诱导的多能干细胞衍生的肥大细胞可用于体外肥大细胞活化测定表现出人肥大细胞的表型和形态特征
- 作者：Ikuno Tatsuya;Ito Shunsuke;Inoue Tomoaki
- 期刊名称：《The Journal of toxicological sciences》 | 2019年第12期
- Human induced pluripotent stem cells;
- Human mast cells;
- High affinitiy-IgE receptor;
- Tryptase;
- Chymase;
- Histamine;
75.Dose- and time-dependent changes in blood and adrenal levels of multiple steroids in rats after administration of ketoconazole with or without ACTH

机译：用或没有acth施用酮康唑后大鼠血液和肾上腺肾上腺水平的剂量和时间依赖性变化
- 作者：Tochitani Tomoaki;Yamashita Akihito;Matsumoto Izumi;Kouchi Mami;Fujii Yuta;Miyawaki Izuru
- 期刊名称：《The Journal of toxicological sciences》 | 2019年第9期
76.Protective effects of rutin on lipopolysaccharide-induced heart injury in mice

机译：芦丁对小鼠脂多糖诱导心脏损伤的保护作用
- 作者：Liu Xianchu;Zheng Lan;Liu Ming;Mo Yanzhi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Rutin;
- Lipopolysaccharide;
- Heart;
- Anti-oxidant;
- Anti-inflammatory;
77.Essentials for starting a pediatric clinical study (3):Dynamic changes in early development of immune system in macaque monkeys-The significance from standpoint of preclinical toxicity test using nonhuman pri mates-

机译：起始儿科临床研究的必需品（3）：猕猴免疫系统早期发展的动态变化 - 从非人类PRI MASS的临床前毒性试验的观点意义 -
- 作者：Keiji Terao
- 期刊名称：《The Journal of toxicological sciences》 | 2009年第2期
78.Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

机译：分解二苯基醚暴露对成人Sprague-Dawley大鼠海马谷氨酸受体亚基的空间学习和记忆，表达及磷酸化
- 作者：Li Xiong;Hao Liyue;Zeng Fancai;Li Maoting;Li Ya;He Ting;Yang Zhen;Zhu Shanshan;Gu Wenwen;Tang Yan
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第12期
- Decabrominated diphenyl ethers;
- Learning and memory;
- Hippocampi;
- Glutamate receptor;
- Phosphorylation;
79.Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism

机译：缬沙甲酸诱导自闭症大鼠模型中的社会行为，神经免疫标记和谷氨酸脱羧酶水平
- 作者：Win-Shwe Tin-Tin;Nway Nay Chi;Imai Motoki;Lwin Thet-Thet;Mare Ohn;Watanabe Hidehiro
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第12期
- Developmental neurotoxicity;
- Valproic acid (VPA);
- Social behavior;
- Autism;
- Glutamic acid decarboxylase (GAD);
- Rat;
80.Monomethylmercury degradation by the human gut microbiota is stimulated by protein amendments

机译：人体肠道微生物会降解人体肠道汞的降解被蛋白质修正刺激
- 作者：Guo Galen;Yumvihoze Emmanuel;Poulain Alexandre J.;Chan Hing Man
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第12期
- Gut microbiome;
- Monomethylmercury;
- Metabolism;
- Mercury;
- Diet;
- Protein;
81.Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice

机译：基于氘 - 肝脏小鼠氘标记的三甲胺的代谢谱，使用药代动力学建模的三甲胺N-氧化物推断的人血浆浓度
- 作者：Shimizu Makiko;Suemizu Hiroshi;Mizuno Sawa;Kusama Takashi;Miura Tomonori;Uehara Shotaro;Yamazaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- PBPK modeling;
- Allometric scaling;
- TMA;
- TMAO;
- Human;
82.Intrauterine environment-genome interaction and Children's development (1): Ethanol: a teratogen in developing brain

机译：宫内环境 - 基因组互动和儿童发展（1）：乙醇：发展大脑的致畸性
- 作者：Yoshihiro Fukui;Hiromi Sakata Haga
- 期刊名称：《The Journal of toxicological sciences》 | 2009年第2期
83.Children's Immunology, what can we learn from animal studies (1):Decidual cells induce specific immune system of feto-maternal interface

机译：儿童免疫学，我们可以从动物研究中学到什么样的动物研究（1）：蜕膜细胞诱导Feto-Maternal界面的特异性免疫系统
- 作者：Orie Nakamura
- 期刊名称：《The Journal of toxicological sciences》 | 2009年第2期
84.Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice

机译：沙利度胺保护针对急性五苯甲酸四唑和小鼠诱导的小鼠诱导的癫痫发作
- 作者：Mara Islas-Espinoza Ana;Campos-Rodriguez Carolina;Ramirez-San Juan Eduardo
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第12期
- Thalidomide;
- Anticonvulsant;
- PTZ;
- Pilocarpine;
- 7-NI;
- Ibuprofen;
85.Effect of the combined compound probiotics with mycotoxin-degradation enzyme on detoxifying aflatoxin B-1 and zearalenone

机译：复合益生菌与霉菌毒素降解酶解毒毒毒素B-1和酸甲酮的效果
- 作者：Huang Weiwei;Chang Juan;Wang Ping;Liu Chaoqi;Yin Qingqiang;Zhu Qun;Lu Fushan;Gao Tianzeng
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Biodegradation;
- Mycotoxin;
- probiotics;
- mycotoxin-degradation enzyme;
- Response surface methodology;
86.Intrauterine environment-genome interaction and Children's development (2):Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams

机译：宫内环境 - 基因组互动和儿童发展（2）：通过单一腹腔（DA）对其水坝的脑部小鼠后代诱导脑结构损伤和行为扰动
- 作者：Kentaro Tanemura;Katsuhide Igarashi;Toshiko R Matsugami
- 期刊名称：《The Journal of toxicological sciences》 | 2009年第2期
87.Effects of ascorbic acid treatment on developmental alterations in calcium-binding proteins and gamma-aminobutyric acid transporter 1 in the cerebellum of lead-exposed rats during pregnancy and lactation

机译：抗坏血酸处理对妊娠期铅暴露大鼠钙结合蛋白和γ-氨基丁酸转运蛋白1的发育变化的影响
- 作者：Nam Sung Min;Seo Jin Seok;Nahm Sang-Soep;Chang Byung-Joon
- 期刊名称：《The Journal of toxicological sciences》 | 2019年第12期
- Lead (Pb);
- Ascorbic acid;
- Cerebellum;
- Calcium-binding protein;
- GABA transporter 1;
88.Estimation of potential risk of allyl alcohol induced liver injury in diabetic patients using type 2 diabetes spontaneously diabetic Torii-Lepr(fa) (SDT fatty) rats

机译：患有2型糖尿病患者糖尿病患者血糖酒精诱导肝损伤的潜在风险的估算自发性糖尿病患者（SDT脂肪）大鼠
- 作者：Takahashi Tadakazu;Matsuura Chizuru;Toyoda Kaoru;Suzuki Yusuke;Yamada Naohito;Kobayashi Akio;Sugai Shoichiro;Shimoi Kayoko
- 期刊名称：《The Journal of toxicological sciences》 | 2019年第12期
- SDT fatty rats;
- Type2 diabetes;
- Hepatotoxicity;
- Glutathione;
- Allyl alcohol;
89.A 13-week subchronic toxicity study of acetaminophen using an obese rat model

机译：肥胖大鼠模型的乙酰氨基酚的13周次级毒性研究
- 作者：Toyoda Takeshi;Cho Young-Man;Akagi Jun-ichi;Mizuta Yasuko;Matsushita Kohei;Nishikawa Akiyoshi;Imaida Katsumi;Ogawa Kumiko
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第9期
- Subchronic toxicity;
- Obese Zucker rat;
- Obesity;
- Acetaminophen;
90.Scientific basis for risk analysis of food-related substances with particular reference to health effects on children

机译：有关食物相关物质风险分析的科学依据，特别是儿童健康影响
- 作者：Yuzo Hayashi
- 期刊名称：《The Journal of toxicological sciences》 | 2009年第2期
91.Fluoride-induced iron overload contributes to hepatic oxidative damage in mouse and the protective role of Grape seed proanthocyanidin extract

机译：氟化铁过载导致小鼠的肝氧化损伤以及葡萄籽原霉素提取物的保护作用
- 作者：Niu Qiang;He Ping;Xu Shangzhi;Ma Ruling;Ding Yusong;Mu Lati;Li Shugang
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第6期
- Fluoride;
- Liver;
- Oxidative stress;
- Iron overload;
- Grape seed proanthocyanidin extract;
92.The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells

机译：抗癌药物Gefitinib通过增强癌细胞中的Caspase-8活化来加速Fas介导的细胞凋亡
- 作者：Sekiguchi Yuto;Yamada Mayuka;Noguchi Takuya;Noomote Chise;Tsuchida Mei;Kudoh Yuki;Hirata Yusuke;Matsuzawa Atsushi
- 期刊名称：《The Journal of toxicological sciences》 | 2019年第6期
- Apoptosis;
- Gefitinib;
- Fas;
- HSP70;
- Chemotherapeutic agent;
93.Expansion of the applicability domain for highly volatile substances on the Short Time Exposure test method and the predictive performance in assessing eye irritation potential

机译：在短时间曝光试验方法上扩展适用性域，在短时间内曝光测试方法和评估眼睛刺激潜力的预测性能
- 作者：Abo Takayuki;Yuki Takuo;Xu Rui;Araki Daisuke;Takahashi Yutaka;Sakaguchi Hitoshi;Itagaki Hiroshi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第9期
- Short time exposure;
- Eye irritation;
- Alternative method;
- Highly volatile substance;
- Draize eye test Reference Database;
94.Stephanthraniline A suppresses proliferation of HCT116 human colon cancer cells through induction of caspase-dependent apoptosis, dysregulation of mitochondrial function, cell cycle arrest and regulation of Akt/p38 signaling pathways

机译：Stephanthraniline通过诱导Caspase依赖性细胞凋亡，线粒体函数的失调，细胞周期停滞和Akt / P38信号传导途径的调节，抑制Hct116人结肠癌细胞的增殖
- 作者：Wang Lu;Yao Li;Li Xiaoyu;Chen Juan;Lou Chenghua;Wang Yiqi
- 期刊名称：《The Journal of toxicological sciences》 | 2019年第9期
- C-21 steroidal aglycone;
- Apoptosis;
- Cell cycle arrest;
- Colon cancer;
95.Low-level lead exposure and cardiovascular disease: the roles of telomere shortening and lipid disturbance

机译：低级铅暴露和心血管疾病：端粒缩短和脂质干扰的作用
- 作者：Nei Liyun;Chen Zhenying;Dai Bo;Li Guilin;Zhu Gaochun
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第12期
- Lead exposure;
- Cardiovascular disease;
- Telomere damages;
- Lipid disturbances;
96.Children's toxicology from bench to bed - Drug-induced Renal Injury (3): Drug transporters and toxic nephropathy in childhood

机译：从长凳到睡觉 - 药物诱发的肾损伤（3）：儿童转运蛋白和童年中有毒肾病的毒理学
- 作者：Takashi Sekine;Hitoshi Endou
- 期刊名称：《The Journal of toxicological sciences》 | 2009年第2期
97.Electropharmacological characterization of microminipigs as a laboratory animal using anti-influenza virus drug oseltamivir

机译：用抗流感病毒药物奥司唑米耐药物作为实验室动物的微粒状物
- 作者：Lubna Nur Jaharat;Nakamura Yuji;Hagiwara-Nagasawa Mihoko;Goto Ai;Chiba Koki;Kitta Kumiko;Izumi-Nakaseko Hiroko;Ando Kentaro;Naito Atsuhiko T.;Akie Yasuki;Sugiyama Atsushi
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第9期
- Microminipig;
- Halothane;
- Safety pharmacology;
- Oseltamivir;
- Short QT;
98.Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl) stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells

机译：TRIS（五氟苯基）二烷基，Tris（五氟苯基）arsane和Tris（五氟苯基）磷酸盐中培养的牛主动脉内皮细胞的方法
- 作者：Fujie Tomoya;Takenaka Fukuta;Yoshida Eiko;Yasuike Shuji;Fujiwara Yasuyuki;Shinkai Yasuhiro;Kumagai Yoshito;Yamamoto Chika;Kaji Toshiyuki
- 期刊名称：《The Journal of toxicological sciences》 | 2019年第6期
- Metallothionein;
- Organometallic compound;
- Endothelial cell;
- Metal response element;
- Antioxidant response element;
99.Verification of a false positive in a two-year rat carcinogenicity study using dual control groups

机译：使用双对照组核实两年大鼠致癌性研究中的假阳性
- 作者：Ogawa Shuji;Kuroda Hiroyuki;Kinomoto Toshiko;Kawabata Yoshihiro;Kawabe Mayumi;Suguro Mayuko;Oishi Yuji
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第9期
- Dual controls;
- Carcinogenicity;
- Endometrial adenocarcinoma;
- Rat;
- Acotiamide;
100.Melatonin antagonizes oxidative stress-induced mitochondrial dysfunction in retinal pigmented epithelium cells via melatonin receptor 1 (MT1)

机译：褪黑素通过褪黑素受体1（MT1）拮抗视网膜着色上皮细胞中的氧化应激诱导的线粒体功能障碍
- 作者：Yang Guigang;Yu Lianzhi;Jiang Songmei;Zhu Jianfeng
- 期刊名称：《The Journal of toxicological sciences》 | 2018年第12期
- Melatonin;
- Mitochondrial dysfunction (MD);
- Oxidative stress (OS);
- Retinal pigmented epithelium (RPE) cells;

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