Efficacy of Oxime Plus Atropine Treatment against Soman Poisoning in theAtropinesterase-Free Rabbit

摘要

The oximes pralidoxime chloride (2-PAM), MMB4, and HI-6 were evaluated incombination with atropine as treatments against soman poisoning in atropinesterase-free rabbits. Animals were challenged i.m. with 2 x LD50 soman and treated at the onset of toxic signs with 50 micron mol/kg of oxime and 5 or 13 mg/kg atropine. Survival and time to death were compared at 48 hours post-soman challenge. Survival rates in MMB4 and HI-6 treated animals were higher than in 2-PAM-treated animals. The increase in survival was significant at the 13 mg/kg dose of atropine. MMB4 and HI-6 also significantly delayed time to death after soman compared to 2-PAM. The results suggest that MMB4 and HI-6 have potential as useful oximes for treating soman poisoning.... Soman, Nerve agent, Treatment, Rabbit, HI-6, 2-PAM, Oxime therapy.