Effects of Cyanide on Neural and Synaptic Function in Hippocampal Slices.

摘要

Transverse slices from guinea pig hippocampi were exposed to micromolar concentrations of sodium cyanide while neural and synaptic function were monitored in the CA1 region. Cyanide concentrations between 10 and 200 micro m rapidly depressed synaptic transmission between Schaffer collateral-commissural fibers and CA1 pyramidal cells. Analysis of input/output curves revealed that the suppression had two components, a decrease in EPSP generation and an increase in action potential threshold. Direct electrical excitability of axons was not affected. At concentrations at 500 Micro M cyanide had no effect on antidromic activation of pyramidal cells. At 1000 Micro M, cyanide caused a moderate depression of the antidromic response in one slice while having no effect in one other. (TTL)