Label-free quantitative hippocampal proteomics reveals pathways linking gamma radiation damage to pathways associated with mitochondrial function, synaptic activity and memory

摘要

Central nervous system damage risks from gamma radiation exposure as part of cancer treatment, dirty bomb scenarios, and military missions are of increasing clinical concern. The hippocampus might be particularly radiation sensitive and radiation-induced hippocampal injury affects neurotransmission and learning and memory. The mechanisms of hippocampal injury and effective mitigation strategies following gamma radiation exposure are still largely unknown. The objective of this study is, to uncover alterations to the hippocampal proteome biology that can link mechanisms of hippocampal injury and dysfunctio to gamma radiation exposure.