Influence of Exogenous Eicosanoids on the Radiation Response of Cultured BovineAortic Endothelial Cells

摘要

Many eicosanoids protect the cells of the gastric and intestinal mucosa fromexposure to acid, ethanol, heat, and other forms of chemical injury. In addition, several eicosanoids consistently have been shown to protect the cell renewal systems of the intestine and bone marrow from radiation damage in vivo. Pretreatment with some eicosanoids has enhanced survival of irradiated mice . Although evidence suggests that the eicosanoids protect by first binding to specific receptors, subsequent events leading to radiation protection are not known. Reports of radiation protection by prostaglandins in vitro have been less consistent in their results and conclusions than those in vivo. Both Prasad and Lehnert reported in vitro radiation protection of CHO cells and V79 cells, respectively, by PGE. These investigators associated elevated levels of adenosine 3',5'-cyclic monophosphate (cAMP) with the radioprotection. PGE is the one prostaglandin that has been shown to have no radioprotective activity in vivo in the mouse intestine.