Molecular studies on tumor cell-vasculature interactions: Adhesion molecules, endothelial cell retraction, tumor cell spreading, and modulatory role of eicosanoid 12(S)-HETE.

摘要

In this project, we studied the molecular mechanisms of tumor cell-vasculature interactions. We focused our research on the role of various adhesion molecules in mediating tumor cell-endothelium and tumor cell-ECM interactions and on the modulatory functions of eicosanoid 12(S)-HETE. First, PECAM-1 was found to be involved in "docking" tumor cells to unstimulated endothelial cells. Subsequently, when endothelial cells are activated by bioactive stimulators such as 12(S)-HETE, integrin receptors such as