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Entrapping of Hydrophobized Plague Capsular Antigen into the Large UnilamellarLiposomes

机译:疏水性瘟疫荚膜抗原包埋入大单层脂质体中

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Liposomes, having adjuvant properties increase the body's immune response to theantigens introduced with them. The immunopotentiating effect depends on the quantity of antigen immobilized in the liposomes, the presence of it on the outer surface of the membrane, lipid composition, size of the vesicles and other conditions. Hydrophilic proteins are adsorbed on the liposome membrane in a small quantity, which reduces immunogenicity of the preparation. Consequently the problem emerged of immobilizing proteins on the outer surface of the vesicles. Diverse methods have been developed in recent years for fixing proteins on the liposome membrane.

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