Reaction of 2-oxoindoin-3-ylidene derivatives with heterocyclic enamines.A convenient one-pot synthesis of pyrimido [5,4:5',6']pyrido[2,3-b]-indole-2,4-dione and spiro indolin-2-one-3,5'-pyrido [2,3-d]pyrimidines

摘要

The reaction of 6-aminouracils 2a,b with 2-oxoindolin-3-ylideneacetophenones 1a-h afforeded Pyrimido[5,4:5',6'] pyrido-[2,3-b]indole-2,4-dones 3 a-k via a regiospecific Michael addition,followed bycyclization.Alternatively,the reaction of 2a with 2-oxoindolin-3-ylidenemalononitriles 6a,b gave rise to regiospecific formation fospiro indolin-2-one-3,5'-pyrido[2,3]d]pyrimidines 7a,b.