Pyrido (2,3-d) pyrimidine derivatives, their use, pharmaceutical compositions containing them, processes for preparing the pyrido (2,3-d) pyrimidine derivatives and intermediates useful in the processes

摘要

The pyrido[2,3-d]pyrimidines are of the formulawherein R² is hydrogen, hydroxy, alkyl, alkylthio, phenyl, 4-methoxyphenyl, 4-chlorophenyl, 1-pyrrolidinyl or methylphenylamino; R⁵ is hydroxy, alkylamino, 2-hydroxyethylamino, 2-alkoxymethylamino, dialkylamino, 4-methyl-1-piperazinyl, 4-morpholinyl or 1-pyrrolidinyl or amino with the provisos that if R⁸ is alkyl and R² is phenyl then$\mathop{\mathrm{image}}$ is other than amino and if R⁸ is alkyl and R² is alkylthio then R⁵ is other than 1-pyrrolidinyl; $\mathop{\mathrm{image}}$ is alkoxy, amino, mono- ordialkylamino, 2-hydroxyethylamino, 2-alkoxymethylamino or 2-(dialkylamino)-ethylamino; and R⁶ is hydrogen, alkyl, 2-alkoxyethyl, allyl, propargyl, phenyl, 4-methoxyphenyl, 4-chlorophenyl, benzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-(4-morpholinyl)-phenyl or piperonyl. The compounds are useful as anti-secretory agents. Some also exhibit anti-allergy activity. Processes for preparing the compounds are described and also novel intermediates useful in the processes.