An Efficient One-pot Synthesis of Novel Spiro Cyclic 2-Oxindole Derivatives of Pyrimido[4,5-b]Quinoline, Pyrido[2,3-d:6,5-d ']Dipyrimidine and Indeno[2 ',1 ':5,6]Pyrido [2,3-d]Pyrimidine in Water

摘要

A novel and facile one-pot synthesis of spiro cyclic 2-oxindole derivatives of pyrimido[4,5-b]quinoline-4,6-dione, pyrido[2,3-d:6,5-d']dipyrimidine-2,4,6-trione, and indeno[2',1':5,6]pyrido [2,3-d] pyrimidine employing 6-aminothiouracil (or 6-aminouracil), isatin, and cyclic 1,3-diketone (e.g. 1,3-indanedione, dimedone, or barbituric acid) has been developed.