Asymmetric Synthesis of (2S)-1-(3,4-dihydroxyphenoxy)-3-(3,' 4 '-dimethoxyphenoxy) ethylamino-2-propanol hydrochloride (RO363)

Narsaiah AV

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Asymmetric Synthesis of (2S)-1-(3,4-dihydroxyphenoxy)-3-(3,' 4 '-dimethoxyphenoxy) ethylamino-2-propanol hydrochloride (RO363)

机译：（2S）-1-（3,4-二羟基苯氧基）-3-（3，'4'-二甲氧基苯氧基）乙氨基-2-丙醇盐酸盐的不对称合成（RO363）

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Enantiomerically pure (S)-RO363 was synthesized by using (R,R) Salen Co(III) complex for the resolution of terminal epoxide. The hydrolytic kinetic resolution process was carried out at room temperature in excellent enantioselectivity. The method can be applied for large-scale preparation of (S)RO363.

机译：使用（R，R）Salen Co（III）配合物合成对映体纯的（S）-RO363，用于拆分末端环氧化物。水解动力学拆分过程在室温下以优异的对映选择性进行。该方法可用于大规模制备（S）RO363。

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来源
《Synthetic Communications 》 |2006年第13期| 共5页
作者
Narsaiah AV;
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正文语种 eng
中图分类有机化学 ;
关键词
catecholamine; enantiomers; jacobsen catalyst; resolution; RO363; KINETIC RESOLUTION; AGONIST;

机译：儿茶酚胺对映体雅各布森催化剂拆分RO363动力学拆分激动剂;

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1. Asymmetric Synthesis of (2S)-1-(3,4-dihydroxyphenoxy)-3-(3,' 4 '-dimethoxyphenoxy) ethylamino-2-propanol hydrochloride (RO363) [J] . Narsaiah AV Synthetic Communications . 2006 ,第13期

机译：（2S）-1-（3,4-二羟基苯氧基）-3-（3，'4'-二甲氧基苯氧基）乙氨基-2-丙醇盐酸盐的不对称合成（RO363）
2. #beta#~1-Selective Agonist (-)-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol[(-)-ro363]differentilly interacts with key amino acids responsible for #beta#_1-selective binding in resting and active states [J] . Yoshiyuki Sugimoto, Reiko Fujisawa, Ryuji Tanimura, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2002 ,第1期

机译：＃beta＃〜1-选择性激动剂（-）-1-（3,4-二甲氧基苯乙氨基）-3-（3,4-二羟基）-2-丙醇[（-）-ro363]与主要负责氨基酸的相互作用＃beta＃_1-处于静止状态和活动状态的选择性绑定
3. Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol ((-)-RO363) differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states. [J] . Sugimoto Yoshiyuki, Fujisawa Reiko, Tanimura Ryuji, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2002 ,第1期

机译：Beta（1）-选择性激动剂（-）-1-（3,4-二甲氧基苯乙氨基）-3-（3,4-二羟基）-2-丙醇（（--RO363）与负责β的关键氨基酸差异相互作用（1）在静止和活跃状态下的选择性结合。
4. Asymmetric Synthesis of 3,4-Dihydrocoumarins by the Rhodium-Catalyzed Reaction of 3-(2-Hydroxyphenyl)cyclobutanones [C] . Masanori Shigeno, Takanori Matsuda, Masahiro Murakami Symposium on Organometallic Chemistry . 2007

机译：通过3-（2-羟基苯基）环丁酮的铑催化反应的3,4-二氢脲ourins的不对称合成
5. I. A1,3- strain enabled retention of chirality during Bis-cyclization of β-ketoamides: Asymmetric synthesis and bioactivity of salinosporamide a and derivatives II. Optimization of an Organic syntheses procedure: asymmetric nucleophile-catalyzed aldol-lactonization with aldehyde acids [D] . Nguyen, Henry 2010

机译：I. A1,3-菌株能够在β-酮基酰胺的双环化过程中保留手性：salinosporamide a和衍生物II的不对称合成和生物活性。有机合成程序的优化：醛酸不对称亲核催化醛醇内酯化
6. 3-[1-(3,4-Dichlorophenyl)ethyl]-1,3-thiazinane-2-thione [O] . Fu-Feng Yan, Chong-Jia Liang 2016

机译：3- [1-（3,4-二氯基）乙基] -1,3-噻嗪基-2-硫酮
7. Stereochemical Assignment of the threo and erythro Forms of 2-(2,6-Dimethoxyphenoxy)-1-(3,4-dimethoxyphenyl)-1,3-propanediol from X-Ray Analyses of the Synthetic Intermediates (Z)-2-(2,6-Dimethoxyphenoxy)-3-(3,4-dimethoxyphenyl)-2-propenoic Acid and threo-2-(2,6-Dimethoxyphenoxy)-3-(3,4-dimethoxyphenyl)-3-hydroxypropanoic Acid. [O] . Knut Lundquist, Rolf Stomberg, Sverker von Unge, 1987

机译：从合成中间体（Z）-2-（Z）-2-（Z）-2-（Z）-2-（Z）-2-（Z）-2-（ 2,6-二甲氧基苯氧基）-3-（3,4-二甲氧基苯基）-2-丙基甲酸和三种-2-（2,6-二甲氧基苯氧基）-3-（3,4-二甲氧基苯基）-3-羟丙酸。

Asymmetric Synthesis of (2S)-1-(3,4-dihydroxyphenoxy)-3-(3,' 4 '-dimethoxyphenoxy) ethylamino-2-propanol hydrochloride (RO363)

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