Feline Mucopolysaccharidosis VII Due to (3-Glucuronidase Deficiency

摘要

Mucopolysacchari-doses (MPS) are lysosomal storage disorders caused by the deficiency of a lysosomal hydrolase needed for mu-copolysacchatide degradation, To date, only MPS I and VI have been reported in cats. The first case of MPS VII in a cat was described. Domestic short-haired male cat, 12-14 weeks old, was seen for assessment of walking difficulty and an enlarged abdomen. Examination revealed coineal clouding, plump front paws with inside rotation, and mild skin thickening, especially over the paws, Mucopolysacchari-dosis was suspected. The result of a toluidine test for sulfated glycosaminogly-cans in the urine was positive Radiographic findings, excessive granulation of neutrophil granulocytes, and intense vacuolation of lymphocytes prompteda biochemical analysis, and beta-glucuronidase deficiency was found.