Refractory status epilepticus in a patient with short bowel syndrome - A microdialysis study

摘要

Status epilepticus (SE) is the second most common neurological emergency, and frequently requires neurointensive care. SE persisting despite treatment with benzodiazepines and antiepi-leptic drugs is defined as refractory status epilepticus (RSE). RSE frequently occurs in people without structural brain damage and carries a mortality rate of up to 40%. While common causes of RSE have been extensively studied, uncommon causes such as autoimmune disorders and mitochondrial, genetic and metabolic diseases like folic acid (FA) deficiency have been explored less and are thus particularly challenging for the treating intensivist. Several therapeutic and diagnostic strategies have been suggested for RSE, but none of these have been tested systematically.