Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus

摘要

P ?=?.02), had greater odds of receiving continuous infusion (AOR, 1.8; 95% CI, 1.01-3.36; P ?=?.047), had longer convulsive seizure duration (AOR, 2.6; 95% CI, 1.38-4.88; P ?=?.003), and had more frequent hypotension (AOR 2.3; 95% CI, 1.16-4.63; P ?=?.02). In addition, the timing of the first-line benzodiazepine treatment was correlated with the timing of the second-line (95% CI, 0.64-0.95; P ??.001) and third-line antiseizure medications (95% CI, 0.25-0.78; P ??.001). Conclusions and Relevance ?Among pediatric patients with RCSE, an untimely first-line benzodiazepine treatment is independently associated with a higher frequency of death, use of continuous infusions, longer convulsion duration, and more frequent hypotension. Results of this study raise the question as to whether poor outcomes could, in part, be prevented by earlier administration of treatment.