Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy

摘要

The Women's Health Initiative (WHI) Study of Cognitive Aging studies have investigated the effects of specific treatment regimens containing a combination of conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA) or CEE only on longitudinal changes in domain-specific cognitive function in older postmenopausal women. In the previous reports, CEE + MPA had a deleterious impact on verbal memory but appeared to have a positive effect on figural memory over time in older postmenopausal women. The present study tests the possibility that CEE alone (unopposed by MPA) could protect against age-related declines in both verbal and figural memory.