SEX STEROID PRECURSORS ALONE OR IN COMBINATION WITH A SELECTIVE ESTROGEN RECEPTOR MODULATOR AND/OR WITH ESTROGENS AND/OR A TYPE 5 CGMP PHOSPHODIESTERASE INHIBITOR FOR THE PREVENTION AND TREATMENT OF VAGINAL DRYNESS AND SEXUAL DYSFUNCTION IN POSTMENOPAUSAL WOMEN

摘要

SEXUAL STEROID PRECURSORS ISOLATED OR IN COMBINATION WITH A SELECTIVE STROGEN RECEIVER MODULATOR AND / OR WITH CGMP STROGEN AND / OR TYPE 5 PHOSPHODIESTERASE INHIBITOR FOR THE PREVENTION AND TREATMENT OF VAGINAL DRY AND PERSONAL MUSPULAR DISFUSION. New methods for treating or reducing the likelihood of acquiring vaginal dysfunction, more particularly vaginal dryness and dyspareunia, leading to sexual dysfunction and low sexual desire and performance, in susceptible warm-blooded animals including humans involving the administration of a sex steroid precursor. . Additional administration of estrogen or selective estrogen receptor modulator, particularly those selected from the group consisting of Raloxifene, Arzoxifene, Tamoxifen, Droloxifene, Toremifene, Iodoxifene, GW 5638, TSE-424, ERA-923, and Lasofoxifene, and more particularly compounds that are have the general structure are specifically disclosed for the medical treatment and / or inhibition of the development of some of the aforementioned diseases. Pharmaceutical compositions for delivery of active ingredient (s) and kit (s) useful for the invention are also disclosed.