Synthesis of Bis(diphenylphosphorylmethyl) ketone

摘要

The complex multistage synthesis of bis(di-phenylphosphorylmethyl) ketone II by the reaction of ;alkyldiphenylphosphinite with [2-(methoxycarbonyl-hydrazone)-3-chloropropyl]diphenylphosphine oxide followed by hydrolysis of the reaction product has been reported earlier [1]. We developed a simpler method of obtaining II by reacting diphenyl-phos-phorylacetic acid with trifluoracetic acid anhydride in the presence of pyridine.