Antifungal Activity, Synthesis and Structure of New Derivatives of 1,2,4-triasole, α-(p-chloro-phenoxy) - α - (1,24-triasole-1-il) Acetic Acid

摘要

The paper presents the synthesis of a new derivative of 1,2,4-triasole, α-(p-chbro-phenoxy) -α-(1,2,4-triasole-1-il) acetic acid, which was characterized by elemental analysis, IR,DSC,UV-VIS, FT-IR, ~1H-RMN, and °C-RMN. With the purpose of determining the active biological potential of the compound, an environment was developed and optimized for breeding four different fungi species: Aspergillus flavus, Trichoderma viride, Alternaria alternata, and Penicillium crysogenum. When the antifungal action of α-(p-chloro-phenoxy) -α-(1,2,4-triasole-1-il) acetic acid was tested, 21 species of cellulosolitic fungi in an isolated pure culture on art objects (paper, textile materials, mural oil paintings, frescoes, glass, stone, and ceramic).