DERIVATIVES OF 3-AMMONIOPROPENYLCEPHEM-4-CARBOXYLATE WITH ANTIBACTERIAL ACTIVITY, DERIVATIVE OF 3-IODOPROPENYLCEPHEM AS AN INTERMEDIATE PRODUCT FOR THE SYNTHESIS OF DERIVATIVES OF 3-AMMONIOPROPENYLCEPHEM-4-CARBOXYLATE, 2-(5-TRITYLAMINO-1,2,4-THIADIAZOL-3-YL)-(Z)-2-FLUOROMETHOXYIMINOACETIC ACID AS AN INTERMEDIATE COMPOUND FOR T

摘要

The invention relates to cephem derivatives, in particular the compounds of the general f-ly I and f-II and III: K-tgC-C (0) - | -f (I) HJiJUb-o-CM, oL-, 1 J-fn. sn-si . .o c-o A- 9 (CHJfD4JCW |) -CHI-C (0) -NH; fCtolNHj, HOH.C, - (Sn,) ,,) - with ((H-ni; -fCMjIj-cf-njfCMjj-ooj-trH. ™ .XS, -OH -KfCHj), - Cf-.H ) (OHJ-C (0) NM ;; - (TJ i Г rf / Urt, ПГ V / I Г CHj-ttOJ-MH, / ° CHtc (omHt CH, OH CM, CH. У; - CMtC (-o CH (CH, -NfCMjVCH.-CfO (CH,), -C (-H) (OH); C (0) NH, (B) (Wl-HH-Cc-cp, .. MHT: r CH CH-cH, J. 5-0-CH1f0j-Nv: c (0) OI N-- C-C | 0) -OH (“) .ocMtf l-Nl CHjJj-CI -CfOI-W; - AND-C #) WH,; CHfCHjl-CJO-MM, {HI Compounds of f-ly I have antibacterial activity that can be used in medicine, compound of f-ly II can be used as an intermediate for the synthesis of 3-ammonium derivatives - ropenylcepheme-4-carboxylate, and compound f-ly III can be used to synthesize p-metox benzyl-7- / - 2- (5-tritylamino-1,2,4-thiadiazol-3-yl) - (Z) - (2-fluoromethoxyiminoacetamido) -3- (Е) - {3-iodo-1 -propen-1-yl} 3-cephemcarboxylate The aim is to create new intermediates for more active cephalosporin antibiotics Synthesis of f-III compound is carried out by hydrolysis of its ethyl ester in the presence of alkali while boiling in an aqueous-ethanolic medium. Synthesis of compound f-ly II is carried out by iodination of the corresponding chloride with NaJ in acetone medium, followed by conversion of the obtained iodide into the target product f-ly I, by treating with an appropriate ammonium compound (containing radical A). New Ј