eNERgizing pluripotent gene transcription.

摘要

Nucleotide excision repair proteins are classically associated with DNA repair. However, a study by Fong et al. (2011) in the most recent issue of Cell demonstrates that the XPC/RAD23B/CETN2 nucleotide excision repair complex additionally functions as a transcriptional coactivator of Oct4/Sox2, critically regulating maintenance and reestablishment of stem cell pluripotency.