Prothymosin-alpha1 prevents necrosis and apoptosis following stroke.

摘要

Prothymosin-a1 (ProTa), a highly acidic nuclear protein of the a-thymosin family, has multiple functions both within and outside of the cell.1 ProTa plays a cytoprotective role by inhibiting apoptosome formation, and it has cell proliferative activity as an extracellular signaling molecule.1 Recently, we found that ProTa is released upon necrotic stress and protects cells from neuronal death through activation of a putative G)(vo)-coupled receptor coupled to phospholipase C and protein kinase Cbeta_(11).