MiR-34a inhibits GBM growth by targeting notch1

摘要

Aberrant expression of microRNAs (miRNAs) has been implicated in cancer initiation and progression. In a new study, Dr. Xiao-Rong Li and co-workers found that microRNA-34a (miR-34a) is significantly downregulated in glioblastoma multiforme (GBM) specimens compared with normal brain tissues. GBM is the most common and most aggressive malignant primary brain tumor in humans. Growth curve and colony formation assays revealed that miR-34a suppresses proliferation of glioblastoma cells, and overexpression of miR-34a could induce apoptosis of glioblastoma cells.