Composition for Inhibiting Tolerance Against Epidermal Growth Factor Receptor Targeting Inhibitor

摘要

The present invention relates to methods for controlling resistance or sensitivity to EGFR (Epidermal Growth Factor Receptor) targeting agents through a peptide that specifically binds to Neuropilin 1 (Neuropilin 1). In addition, resistance or sensitivity to EGFR targeting agents through co-administration of a fusion antibody in which a peptide specifically binding to neuropilin 1 is fused to an EGFR target antibody and an EGFR targeting agent and the antibody heavy chain constant region fused with the peptide It relates to a composition for conditioning. In addition, the fusion antibody in which a peptide specifically binding to neuropilin 1 according to the present invention is fused to an EGFR target antibody overcomes resistance to the EGFR target antibody in pancreatic cancer. In addition, the fusion antibody in which a peptide specifically binding to neuropilin 1 is fused to an EGFR target antibody overcomes resistance to the EGFR target antibody even in lung cancer having resistance to the EGFR target antibody. Therefore, through the peptide specifically binding to neuropilin 1 according to the present invention, a high effect can be expected in the treatment of various tumors resistant to EGFR-targeting agents.