Aerobic oxidative synthesis of benzimidazoles from amines catalyzed by 3-methyl-4-oxa-5-azahomoadamantane and iron(III) chloride

摘要

A simple and efficient catalytic system including 3-methyl-4-oxa-5-azahomoadamantane and FeCl3 for aerobic oxidative synthesis of benzimidazoles from primary amines and o-phenylenediamine is presented. This process uses O-2 as economic and green oxidant and water as green solvent, tolerates a wide range of substrates, and can afford the target products in moderate to excellent yields.