Antihyperglycemic and Antioxidant potentials Psidium guajava leaf extract and its isolated fraction in alloxan-induced diabetic rats

摘要

In diabetes, hyperglycaemia generates reactive oxygen species, which in turn cause lipid peroxidation and membrane damage and these free radicals play an important role in the production of secondary complications in diabetes. Wistar albino rats aged 6-8 week were selected for the experiments and these were divided into five groups. Diabetes was induced by alloxan. Blood glucose and hepatic antioxidant levels were measured. Psidium guajava and its isolated fraction restored the activities of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). It further decreased the hepatic lipid peroxidation as evidenced by decreased thiobarbituric acid reactive substances (TBARS) level with a concomitant increase in the reduced glutathione (GSH). Psidium guajava has a significant antihyperglycemic effect, and that this effect is associated with its antioxidative activity.