Evaluation of the Chemoprotective Activity of 70% Methanolic Extract of Gmelina arborea Stem Bark against Cyclophosphamide Induced Toxicity

摘要

Cancer results from a series of molecular events that fundamentally alter the normal properties of cells in our body. The normal control systems in cancer cells that prevent cell overgrowth and the invasion of other tissues are disabled. Treatment for cancer should not begin until the presence of cancer is confirmed by a tissue (i.e., histologic) diagnosis. Chemoprotective agents are the drugs that are used with certain types of chemotherapy to protect the body from or minimize the side effects of the chemotherapy. Chemoprotective agents include amifostine, mesna and dexrazoxane. The present study is done to evaluate the chemoprotective efficacy of the Plant Gmelina arborea against cyclophosphamide induced toxicity, as the well known cancer treating drug has number of side effects especially toxicity towards hematopoetic system.