Synthesis of peptides employing Fmoc-/Boc-/Z-amino acid fluorides and activated commercial zinc dust

摘要

The coupling of urethane protected amino acid fluorides is accomplished in the presence of activated, commercial zinc dust to synthesize several di- and tripeptides. The coupling was fast and racemization free. The yield as well as purity of the peptides was satisfactory. The method was extended for the incorporation of sterically hindered α,α-dialkylamino acids and N-methylamino acids as well.