Taurine improves lipid profile in rats fed a high fructose-diet

摘要

The effect of taurine on lipid metabolism in male Wistar rats fed a fructose-rich diet (60%w/w) was investigated. Fructose feeding caused significant elevations in the concentrations of plasma triglycerides and free fatty acids. High-density lipoprotein cholesterol (HDL-C was significantly reduced and very low-density lipoprotein cholesterol (VLDL-C) was significantly elevated. Activities of lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) in plasma were reduced significantly (p<0.001) as compared to animals fed starch diet. Alterations in the activities of plasma cholesterol ester hydrolase (CEH) and cholesterol ester synthetase (CES) were observed in fructose-fed rats. Fructose feeding also induced alterations in fatty acid composition of liver lipids. Simultaneous administration of taurine in drinking water along with fructose diet mitigated the effects of fructose. These rats showed near-normal levels of the parameters studied. We conclude that taurine normalizes the plasma and liver lipid alterations in this nutritional experimental model.