Isolated polypeptide encoded by a lipase-like gene, composition, pharmaceutical composition, antigenic fragment, isolated nucleic acid, vector, recombinant cell, antibody, hybridoma cell, processes for preparing a polypeptide, to screen agonists or antagonists of llg activity, for the enzymatic hydrolysis of a phosphatidylcholine ester, and to improve the lipid profile in the serum of a human or other animal having an undesirable lipid profile, and, transgenic mouse.

摘要

"ISOLATED POLYPEPTIDE CODED BY A LIPASE-LIKE GENE, COMPOSITION, PHARMACEUTICAL COMPOSITION, ANTIGENIC FRAGMENT, ISOLATED NUCLEIC ACID, VECTOR, RECOMBINANT CELL, ANTIBODY, HYDROMATIC HYDROMATIC CELL, ENZYMATIC HYDROLYSIS OF A PHOSPHATIDYLCHOLINE ESTER, AND TO IMPROVE THE LIPID PROFILE IN THE SERUM OF A HUMAN OR OTHER ANIMAL HAVING AN UNDESIRABLE LIPID PROFILE, AND, TRANSGENIC MOUNTAIN. " Polypeptides similar to lipoprotein lipase, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are described. Also described are processes for preparing said polypeptides in a recombinant system and for using said polypeptides to screen agonists or antagonists of said polypeptides. Also described are processes and compositions for the treatment of lipid metabolism disorders.