Asymmetric direct aidol reactions catalyzed by chiral amine macrocycle-metal(II) complexes under solvent-free conditions

摘要

Solvent-free asymmetric aldol reactions between cyclohexanone and 4-nitrobenzaldehyde using chiral amine macrocycle-metal(II) complexes as catalysts in a ball mill afforded the anti-aldol product as the major isomer with up to 93% ee.