Chiral phosphorus cyclic compounds for transition metal-catalyzed asymmetric reactions

摘要

Chiral phospholanes having biaryl chirality for applications in asymmetric catalysis are provided. A series of new chiral mono- or bidentate phosphorus ligands were efficiently prepared through a key intermediate (S)-4-chloro-4,5-dihydro-3H-4-phospha-cyclohepta[2,1-a;3,4-a′]binaphthalene and its derivatives. These ligands were complexed with transition metals to prepare catalysts, which were used in asymmetric catalytic reactions, such as, asymmetric hydrogenation, hydride transfer, allylic alkylation, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, olefin metathesis, hydrocarboxylation, isomerization, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition; epoxidation, kinetic resolution or [m+n] cycloaddition wherein m=3 to 6 and n=2.