Hexafluoroacetone as protecting and activating reagent. Glycosylated malic, citramalic, and thiomalic acid derivatives, new glycosylated building blocks for drug design

Bottcher C; Spengler J; Burger K

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Hexafluoroacetone as protecting and activating reagent. Glycosylated malic, citramalic, and thiomalic acid derivatives, new glycosylated building blocks for drug design

机译：六氟丙酮作为保护和活化剂。糖基化苹果酸，柠檬酸和硫代苹果酸衍生物，新的糖基化药物设计基石

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Glycosylated a-hydroxy and a-mercapto acids have been synthesized starting from malic/citramalic/thiomalic acid and Ac-4-beta-D-Glc-NH2/Bzl(4)-beta-D-Glc-NH2 using hexafluoroacetone as protecting and activating reagent.

机译：糖基化的α-羟基酸和α-巯基酸是从苹果酸/柠康酸/硫代苹果酸和Ac-4-beta-D-Glc-NH2 / Bzl（4）-beta-D-Glc-NH2开始合成的，使用六氟丙酮作为保护剂和活化剂。

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《Monatshefte fur Chemie》 |2004年第10期|共18页
作者
Bottcher C; Spengler J; Burger K;
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正文语种 eng
中图分类化学;
关键词
alpha-hydroxy acids; alpha-mercapto acids; dielectrophiles; glycosylamines; maleimido sugars; 3-hydroxysuccinimido sugars; N-glycosylated depsipeptides; alpha-hydroxyacylamino acids; alpha-mercaptoacylamino acids; GLYCOPEPTIDE ANALOGS; INHIBITOR; OLIGOSACCHARIDES; GLYCOBIOLOGY; STRATEGY; PEPTIDES; ESTERS;

机译：α-羟基酸;α-巯基酸;二亲电子试剂;糖胺;马来酰亚胺糖;3-羟基琥珀酰亚胺基糖;N-糖基化二肽;α-羟基酰基氨基酸;α-巯基氨基酸;糖肽类似物;抑制剂;寡糖;糖苷;糖基酯类;

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专利

1. Hexafluoroacetone as protecting and activating reagent. Glycosylated malic, citramalic, and thiomalic acid derivatives, new glycosylated building blocks for drug design [J] . Bottcher C, Spengler J, Burger K Monatshefte fur Chemie . 2004,第10期

机译：六氟丙酮作为保护和活化剂。糖基化苹果酸，柠檬酸和硫代苹果酸衍生物，新的糖基化药物设计基石
2. Hexafluoroacetone as a Protecting and Activating Reagent.Regioselective Esterification of Aspartic,Malic,and Thiomalic Acid [J] . Ksenia Pumpor, Elisabeth Windeisen, Klaus Burger Monatshefte fur Chemie . 2004,第11期

机译：六氟丙酮作为保护和活化试剂。天门冬氨酸，苹果酸和硫代马来酸的区域选择性酯化
3. Facile synthesis of N- and O-glycosylated alpha-aminooxy acids as building blocks for the structural studies of glycosylated pseudopeptides [J] . Shin I., Lee J. Synlett . 2000,第9期

机译：N-和O-糖基化的α-氨基氧基酸的简便合成，可作为糖基化假肽结构研究的基础
4. HEXAFLUOROACETONE AS A VERSATILE PROTECTING/ACTIVATING REAGENT FOR BETA-HYDROXY ACIDS, SERINE AND THREONINE [C] . Jan Spengler, Javier Ruiz-Rodriguez, Francesc Yraola the European Peptide Symposium . 2007

机译：六氟丙酮作为β-羟基酸，丝氨酸和苏氨酸的通用保护/活化试剂
5. Glycosylating enkephalins: Design, glycosylation using sugar acetates in the preparation of glycosyl amino acids for glycopeptide syntheses, binding at the opioid receptors and analgesic effects. [D] . Keyari, Charles Mambo. 2007

机译：糖基化脑啡肽：设计，使用乙酸糖进行糖基化以制备用于糖肽合成的糖基氨基酸，在阿片样物质受体上的结合和止痛作用。
6. Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation [O] . Nianhuan Yao, Gabriel Fung, Hamed Malken, -1

机译：微波辐射辅助糖基化的FMOC氨基酸构建块的容易合成
7. Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation [O] . Nianhuan Yao, Gabriel Fung, Hamed Malekan, 2010

机译：微波辐射辅助糖基化的FMOC氨基酸构建块的容易合成

Hexafluoroacetone as protecting and activating reagent. Glycosylated malic, citramalic, and thiomalic acid derivatives, new glycosylated building blocks for drug design

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