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A novel building block approach for designing affinity ligands for glycosylated haemoglobin HbA1c
A novel building block approach for designing affinity ligands for glycosylated haemoglobin HbA1c
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机译:设计糖基化血红蛋白HbA1c亲和配体的新型构建基方法
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摘要
An affinity ligand is constructed from at least 3 domains: (1) a recognition domain, e.g. a 3-6 amino acid chain specific for a peptide region of a target; this may be discovered and/or optimised by fitting candidate structures or parts thereof to a model of the target in a computer memory; (2) an affinity domain, e.g. a domain capable of binding to a particular type of region of the target such as a glycosylation region; and (3) a flexible linker having a functional group enabling the ligand to be immobilised to a sensor surface to create a specific biosensor.
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