Hexafluoroacetone as a Protecting and Activating Reagent.Regioselective Esterification of Aspartic,Malic,and Thiomalic Acid

摘要

Hexafluoroacetone reacts with alpha-functionalized alpha,beta-dicarboxy acids like aspartic,malic,and thiomalic acid to give exclusively five-membered lactones.The beta-carboxylic groups remain unaffected and can be derivatized separately.They can be linked La.to orthogonal protecting groups or multivalent alcohols like pentaerythritol to give synthetically valuable building blocks.