One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles via Huisgen 1,3-dipolar cycloaddition catalysed by SiO2-Cu(I) oxide and single crystal X-ray analysis of 1-benzyl-4-phenyl-1H-1,2,3-triazole

摘要

A one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles via Huisgen 1,3-dipolar cycloaddition reaction between terminal alkynes, benzyl/allyl/alkyl halides, and NaN3 in water at room temperature using silica-supported copper(I) oxide (SiO2-Cu2O) has been developed. Various supported copper(I) oxide catalysts have been tested for this reaction where silica-supported copper(I) oxide works well in this reaction. The catalyst being heterogeneous can be easily recovered at the end of reaction and can be reused making the process completely economical. A single crystal X-ray analysis of 1-benzyl-4-phenyl-1H-1,2,3-triazole has revealed that the compound crystallizes in the monoclinic space group P21.