Alzheimer disease. Frontal cortex biopsy samples can predict Alzheimer disease.

摘要

The presence of both amyloid-(3 (A(3) and hyperphosphorylated tau in frontal cortex biopsy samples is a strong indicator of future Alzheimer disease (AD), according to a new study. "The fact that Abeta from living brain tissue predicts the development of clinical AD is in line with the amyloid hypothesis, postmortem studies and molecular imaging," says Ville Leinonen, lead author of the new study. However, "many patients with Abeta develop a clinical dementia other than AD.