Anti-obesity effect of Sargassum confusum ethanol extract in obese rats.

摘要

The effect of Sargassum confusum extract on the reduction of body weight gain and lipid contents in obese rats were evaluated to find natural products with antiobesity activity. After inducing obesity by feeding a high-fat diet for 5 wk, Sprague-Dawley rats were randomly assigned to a high fat diet control (HFD) group and a high fat diet containing 3% S. confusum extract (HFDSC) group. Weight gain of the HFD group (2.96 +or- 0.31 g/day) was significantly (P < 0.05) higher compared to a group fed a normal diet (ND; 2.19 +or- 0.17 g/day). Adipose tissue wt. of the HFD group were higher than those of the ND group. Body weight gain of the HFDSC group was 2.36 +or- 0.24 g/day, which was significantly (P < 0.05) lower than that of the HFD group. In addition, wt. of epididymal and perirenal adipose tissues were lower by 15% and 16%, respectively, as compared to those of the HFD group. Biochemical analyses showed that concn. of triglycerides, total cholesterol, and fatty acids were significantly (P < 0.05) lower in the HFDSC group. These results suggest that S. confusum extract has potential as an antiobesity product, by reducing weight gain and obesity related factors in the serum.